J Potempa Selected Research

Gingipain Cysteine Endopeptidases

2/2017	Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids.
6/2013	Benzamidine derivatives inhibit the virulence of Porphyromonas gingivalis.
6/2009	Gingipain enzymes from Porphyromonas gingivalis preferentially bind immobilized extracellular proteins: a mechanism favouring colonization?
5/2008	Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease-activated receptors with Toll-like receptor and NOD1/2 ligands in human monocytic cells.
8/2006	Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II).
10/2003	Proteolysis of ICAM-1 on human oral epithelial cells by gingipains.
10/2001	Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues.
7/2001	Inhibition of distant caspase homologues by natural caspase inhibitors.
2/2001	Mechanisms mediating Porphyromonas gingivalis gingipain RgpA-induced oral mucosa inflammation in vivo.
1/2001	Activation of blood coagulation factor IX by gingipains R, arginine-specific cysteine proteinases from Porphyromonas gingivalis.

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J Potempa Research Topics

Disease

15	Periodontitis 01/2020 - 01/2000
8	Periodontal Diseases (Periodontal Disease) 06/2009 - 01/2000
7	Chronic Periodontitis 09/2015 - 01/2001
5	Infections 09/2015 - 03/2000
4	Bone Resorption 04/2017 - 10/2000
3	Aggressive Periodontitis (Periodontosis) 08/2013 - 06/2009
2	Hereditary Gingival Fibromatosis 10/2017 - 08/2014
2	Gingivitis 02/2012 - 03/2001
1	Communicable Diseases (Infectious Diseases) 01/2020
1	Septic Shock (Toxic Shock Syndrome) 12/2018
1	Sepsis (Septicemia) 12/2018
1	Alveolar Bone Loss 04/2017
1	Tooth Loss 12/2014
1	Dental Plaque 06/2013
1	Virus Diseases (Viral Diseases) 01/2013
1	Cowpox 07/2001
1	Cardiovascular Diseases (Cardiovascular Disease) 06/2001
1	Inflammation (Inflammations) 02/2001

Drug/Important Bio-Agent (IBA)

11	Gingipain Cysteine EndopeptidasesIBA 02/2017 - 09/2000
9	Peptide Hydrolases (Proteases)FDA Link 02/2012 - 01/2000
6	Cysteine Proteases (Cysteine Protease)IBA 05/2008 - 09/2000
5	Virulence Factors (Pathogenicity Factors)IBA 06/2013 - 10/2001
4	EnzymesIBA 08/2009 - 01/2000
3	Peptides (Polypeptides)IBA 12/2018 - 08/2008
3	Immunoglobulin G (IgG)IBA 04/2017 - 08/2013
3	Arginine (L-Arginine)FDA Link 08/2001 - 09/2000
3	Thrombin FDA Link 06/2001 - 10/2000
2	Interleukin-1 (Interleukin 1)IBA 06/2001 - 01/2001
2	ProstaglandinsIBA 06/2001 - 01/2001
1	Histone Deacetylase InhibitorsIBA 01/2020
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2020
1	temporinIBA 12/2018
1	EndotoxinsIBA 12/2018
1	EnkephalinsIBA 12/2018
1	CytosineIBA 10/2017
1	VaccinesIBA 12/2016
1	InflammasomesIBA 09/2015
1	Interleukin-17 (Interleukin 17)IBA 09/2015
1	Purinergic P2X7 ReceptorsIBA 09/2015
1	Dinoprostone (PGE2)FDA Link 12/2014
1	Protein-Arginine DeiminasesIBA 12/2014
1	CollagenIBA 08/2014
1	IronIBA 06/2013
1	Pentamidine (NebuPent)FDA LinkGeneric 06/2013
1	protoporphyrin IXIBA 06/2013
1	Toll-Like Receptor AgonistsIBA 01/2013
1	Secretory Leukocyte Peptidase InhibitorIBA 02/2012
1	Serine Proteases (Serine Protease)IBA 02/2012
1	Pancreatic Elastase (Elastase)IBA 02/2012
1	Protease Inhibitors (Protease Inhibitor)IBA 02/2012
1	ElafinIBA 02/2012
1	Leukocyte Elastase (Neutrophil Elastase)IBA 06/2009
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2009
1	Hemagglutinins (Hemagglutinin)IBA 06/2009
1	Peroxidase (Myeloperoxidase)IBA 08/2008
1	Antimicrobial PeptidesIBA 08/2008
1	ChlorhexidineIBA 08/2006
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 10/2003
1	Anti-Bacterial Agents (Antibiotics)IBA 10/2001
1	Cysteine Proteinase InhibitorsIBA 10/2001
1	TetracyclinesIBA 10/2001
1	CytokinesIBA 07/2001
1	aspartyllysineIBA 07/2001
1	SerpinsIBA 07/2001
1	HistatinsIBA 03/2001
1	Factor IXa (Coagulation Factor IXa)IBA 01/2001
1	OligopeptidesIBA 01/2001
1	Factor IX (Coagulation Factor IX)FDA LinkGeneric 01/2001
1	Ethylene Glycol (Monoethylene Glycol)IBA 01/2001
1	BradykininIBA 10/2000
1	Indicators and Reagents (Reagents)IBA 10/2000
1	Kallikreins (Kallikrein)IBA 10/2000
1	KininsIBA 10/2000